Job Description

Are you ready to join Connecticut Innovation’s vibrant community of innovators? Connecticut Innovations (“CI”) is Connecticut’s strategic venture capital arm, and we are passionate about serving our portfolio of 220+ companies across various industries, with strengths in life sciences, technology, and climate tech.

Come join encapsulate.bio | as a Bioinformatics Scientist – AI, Imaging & Space-Oncology Research!

Encapsulate Overview

Encapsulate is a venture-backed MedTech pioneer transforming precision diagnostics for personalized cancer therapy. Our proprietary tumor-on-a-chip platform leverages advanced microfluidics and patient-derived organoid technologies to rapidly deliver precise, actionable treatment insights to oncologists. We screen patient-specific microtumors against clinical treatment regimens within days, dramatically improving patient outcomes and reducing unnecessary treatment side effects. Every cancer patient’s tumor is unique—our solutions are tailored to match that uniqueness.

• Technology initially developed at UConn, with ongoing headquarters at UConn’s Technology Incubator in Farmington, CT.

Recently completed oversubscribed seed funding led by Blackwood Healthcare Breakthroughs, Ambit Health Ventures, and Connecticut Innovations.

Why Join Encapsulate?

• Addressing the $4 billion precision diagnostics market, initially targeting colorectal and pancreatic cancers.
• Tackling unmet needs such as ineffective chemotherapy cycles, escalating treatment costs, and chemotherapy-associated toxicities.
• Internationally recognized: 2nd place at the 2024 Entrepreneurship World Cup Global Finals.
• Named “Innovator of the Month” by U.S. Senator Chris Murphy (D-Conn.), July 2024.
• Successfully launched our tumor-on-a-chip technology to the International Space Station in March 2024.
• Funded by a Small Business Innovation Research (SBIR) award from the U.S. National Science Foundation and NASA.

Position Overview

We are seeking a Bioinformatics Scientist with advanced expertise in AI-driven imaging analysis and multi-omics integration to support a suite of NASA-funded experiments at the interface of oncology and space medicine. This position will lead computational efforts in analyzing datasets from spaceflight-exposed cancer organoids, International Space Station (ISS) experiments, and microgravity studies.

You’ll work closely with a cross-functional team of molecular biologists, engineers, and translational oncology experts to extract mechanistic insights from both Earth-based and space-derived models.

• Develop and deploy AI/ML pipelines for the analysis of histological and spatial imaging data (e.g., 3D microscopy, H&E, multiplex IF).
• Perform multi-omics integration (e.g., RNA-seq, single-cell, proteomics) from organoid models flown aboard the ISS Laboratory .
• Analyze datasets from NASA resources such as GeneLab , Life Sciences Data Archive (LSDA) , and in-house studies.
• Co-develop spatially-resolved omics pipelines in combination with AI-based histopathological analysis.
• Collaborate on study design, data interpretation, and preparation of grant reports, publications, and patent filings .

Minimum Qualifications

• Ph.D. in Bioinformatics, Computer Science or Engineering, Computational Biology, Biomedical Engineering, or a related field.
• Demonstrated expertise in machine learning, computer vision , and biomedical image analysis .
• Experience with Python, R , and ML libraries such as PyTorch, TensorFlow , or scikit-learn or other AI tools.
• Proficiency in analyzing omics datasets and pipelines (e.g., STAR, Seurat, DESeq2).
• Track record of peer-reviewed publications in cancer biology, bioinformatics, or computational imaging.

Preferred Qualifications

• Experience working with space biology datasets , including NASA GeneLab , ISS research data , or microgravity analog platforms.
• Familiarity with spatial transcriptomics, digital pathology tools (e.g., QuPath , CellProfiler , Napari ), or radiomics workflows.
• Comfortable working in fast-paced biotech or startup environments.

What We Offer

• Opportunity to work on first-in-kind cancer models in space .
• Collaboration with NASA and leading spaceflight researchers.
• Exposure to translational medicine, automated organoid screening, and mission-critical biology.
• Competitive compensation package with equity options.

Equal Opportunity Employer

Encapsulate is an equal-opportunity employers committed to fostering an inclusive, diverse work environment. We provide competitive compensation, generous benefits, and robust personal leave policies, ensuring a rewarding and empowering professional environment.

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